Once the Boruto: Naruto Next Generations anime started, the director stated that, whereas to start with Mitsuki and Sarada Uchiha had been only classmates, the 2 would have "a more developed relationship from now on". The manga series Boruto: Naruto Next Generations (2016) by Ukyō Kodachi and Mikio Ikemoto begins by retelling the events from the movie, but afterward both Mitsuki and Sarada reject a ninja mission in order to avoid wasting Boruto from an assassin. He later accepts a mission to help Boruto, Kawaki, Sarada, Shikadi, Inojin, and ChoCho keep an eye on Eida and Daemon. In an anime-exclusive arc, Mitsuki seemingly defects from the Leaf Village, and his buddies go on a mission to prove his innocence to their superiors. After this arc, Mitsuki and his associates change into ninjas after passing a test, and he, Boruto, and Sarada type the brand new "Team 7" underneath the leadership of Konohamaru. By the events of the film Boruto: Naruto the Movie (2015), Mitsuki has turn out to be a ninja on a group with protagonist Boruto Uzumaki and Sarada Uchiha, taking a lead function in Ukyō Kodachi and Mikio Ikemoto's manga sequel to Naruto, Boruto: Naruto Next Generations (2016), and its anime prequel, which exhibits how he turned associates with Boruto while going through totally different enemies.

By the occasions of the movie Boruto: Naruto the Movie (2015), Mitsuki has become a low-rating ninja, Genin, teaming up with Boruto Uzumaki and Sarada Uchiha, and led by Konohamaru Sarutobi. After the publish-credit scene, Mitsuki confesses to Boruto and Sarada that he's the son of the criminal Orochimaru, shocking Sarada. Boruto anime director Hiroyuki Yamashita commented on Mitsuki's half in the film, saying that he was rather more of a gentle character. Similarly, Amy McNulty of Anime News Network praised Daymond's efficiency, saying that whereas being "calm, collected, and oftentimes emotionless, the voice helps lend the character much of his thriller". Nik Freeman of Anime News Network discovered Mitsuki's backstory top-of-the-line within the franchise's history as a result of it was not a rehash of prior story arcs. Everyone involved in the project ought to share the news with their mates immediately (or no less than those who would be interested), Gundam Carpet and you'll go on the lookout for followers and fan pages of similar tasks -- as long as you're confident your strategy will not appear to be spam. He originally had a shoulder length bob, but the creator determined to vary his hair to make him look more appealing, giving him a brief white hairstyle as an alternative.