"Our work challenges the textbook model of how the brain fuels itself. Neurons are extra self-ample than we thought," Singh stated. Co-creator Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, mentioned the research supports the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer rapid shifts in power demand," Colón-Ramos stated. Other authors, all from Yale, include Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate pupil in cell biology; Anjali A. Vishwanath and Anastasia Tsives, put up-doctoral researchers in neuroscience; and Richard Goodman, a analysis scientist in neuroscience. Original Research: Open access. "Glycogen supports glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the most important energy reserve in the mind, but the specific role of glycogen in supporting neuronal energy metabolism in vivo isn't properly understood. We performed an RNAi display screen and recognized that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We determined that neurons employ a minimum of two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-independent glycolytic plasticity. We uncover that GDGP is employed beneath conditions of mitochondrial dysfunction, similar to transient hypoxia or in mutants for mitochondrial function.

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